This medication belongs to a class of medication known as β1-selective adrenergic blocker (beta-blocker) , It selectively and competitively blocks catecholamine (adrenaline) stimulation of β1 adrenergic receptors (adrenoreceptors), which are mainly found in the heart muscle cells and heart conduction tissue (cardiospecific), but also found in juxtaglomerular cells in the kidney. It decreases the adrenergic tone/stimulation of the heart muscle and pacemaker cells. Decreased adrenergic tone shows less contractility of heart muscle and lowered heart rate of pacemakers.
This medication is also known as Zebeta, Monocor, Apo-Bisoprolol, Teva-Bisoprolol, Sandoz-Bisoprolol, AG-Bisoprolol, Dom-Bisoprolol, Bisoprolol, and others.
This medication is available in 5mg, and 10mg tablets.
This medication is approved for the management of:
- Cardiovascular events following a heart attack in patients with risk factors for disease progression.
- Congestive heart failure with reduced ejection fraction, and as a second-line agent for hypertension.
- High blood pressure, but it is not recommended as a first-line anti-hypertensive agent without an accompanying comorbid condition, for example, congestive heart failure.
- In cardiac ischemia, the drug is used to reduce the activity of the heart muscle, so reduces oxygen and nutrient demand, and reduced blood supply can still transport sufficient amounts of oxygen and nutrients.
Hypertension
2.5-5 mg PO qDay; may increase to 10 mg and if necessary to 20 mg PO qDay
Heart Failure
1.25 mg PO qDay; increase gradually if necessary not to exceed 10 mg/day
Bisoprolol should be taken with or without food.
There is no drug-food interaction.
Use During Pregnancy:
Pregnancy Category:
Use During Breastfeeding And Lactation:
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose.
Take your next dose at a regular time.
Do not double the dose to catch up.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
This medication might cause some side effects including:
Common side effects:
- Dizziness
- Insomnia
- Slow, irregular heartbeats
- Upper respiratory infection
- Diarrhea
- Runny or stuffy nose
- Joint pain
- Cough
- Shortness of breath
- Nausea
- Sore throat
- Sinus infection (sinusitis)
- Vomiting
- Tiredness
- Drowsiness
- Lightheadedness upon standing
- Spinning sensation (vertigo)
- Dry mouth
- Stomach pain
- Constipation
- Increased urination
- Ringing in your ears
- Weakness
- Sleep problems (insomnia)
- Anxiety
- Restless feeling
- Muscle pain
- Itching or skin rash
- Loss of interest in sex
Less common side effects of bisoprolol include:
- Cold extremities
- Low blood pressure (hypotension)
- Depression
- Indigestion
- Bronchospasm
Rare but serious side effects of bisoprolol include:
- Very slow heartbeat
- Severe dizziness
- Fainting
- Blue fingers/toes
- Trouble breathing
- Mental/mood changes (such as confusion, mood swings, depression)
Other side effects of bisoprolol include:
- Aggravate congestive heart failure (CHF)
- Decrease HDL
- Hypertriglyceridemia
- Mask symptoms of low blood sugar (hypoglycemia)
- Decreased exercise tolerance
- Raynaud's phenomenon
- May increase triglyceride levels and insulin resistance
Renal Impairment
Creatinine clearance:
- Greater than 40 mL/min: Dose adjustment is not necessary
- Less than 40 mL/min: 2.5 mg/day initially; titrate slowly and monitor
Store at room temperature away from light and moisture. Do not store it in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Not Applicable
